Modeling Inhibitors of Matrix Metalloproteinases

图书简介

Matrix metalloproteinases (MMPs) have been established as promising biomolecular targets for novel drug design and discovery against numerous major disease conditions including various cancers, cardiovascular, neurodegenerative, inflammatory diseases, and more. This book covers various modern molecular modeling methodologies particularly related to MMP inhibitors. Included in the text are descriptions of ligand-based drug designing and structure-based drug designing modeling strategies for designing potential and target specific or selective MMPIs. This book will benefit those who are looking for an in-depth text on the design and discovery processes of novel and selective MMPIs.FeaturesDescribes modeling strategies applied to MMPsElaborates on the designing strategies of MMPs specificallyIncludes in-depth analyses of related case studiesActs as a guide for medicinal chemists, not only from pharmaceutical industries, but also from academiaCovers various modern molecular modeling methodologies particularly related to MMPIs

Part A: Fundamentals of molecular modeling Chapter 1 2D-QSAR studies: Regression and classification-based QSAR studies By Sanjib Das, Sk. Abdul Amin, Shovanlal Gayen, and Tarun Jha Chapter 2 3D-QSAR studies: CoMFA, CoMSIA and Topomer CoMFA methods By Suvankar Banerjee, Sandip Kumar Baidya, Nilanjan Adhikari , Tarun Jha Chapter 3 Other modeling approaches: Pharmacophore mapping, molecular docking and molecular dynamic simulation studies By Sk. Abdul Amin, Shovanlal Gayen, Sanjib Das, and Tarun Jha Part B: Matrix metalloporteinases and their inhibitors Chapter 4 Collagenases and their inhibitors By Sandip Kumar Baidya, Suvankar Banerjee, Nilanjan Adhikari, and Tarun Jha Chapter 5 Gelatinases and their inhibitors By Sk. Abdul Amin, Sanjib Das, Shovanlal Gayen, and Tarun Jha Chapter 6 Stromelysins and their inhibitors By Sandip Kumar Baidya, Suvankar Banerjee, Nilanjan Adhikari , and Tarun Jha Chapter 7 Matrilysins and their inhibitors By Sandip Kumar Baidya, Suvankar Banerjee, Nilanjan Adhikari , and Tarun Jha Chapter 8 Membrane-type MMPs and their inhibitors By Suvankar Banerjee, Sandip Kumar Baidya, Nilanjan Adhikari, and Tarun Jha Chapter 9 Other MMPs and their inhibitors By Suvankar Banerjee, Sandip Kumar Baidya, Nilanjan Adhikari, and Tarun Jha Part C: Modeling of MMP inhibitors Chapter 10 Modeling inhibitors of Collagenases By Sandip Kumar Baidya, Suvankar Banerjee, Nilanjan Adhikari, Balaram Ghosh, and Tarun Jha Chapter 11 Modeling inhibitors of Gelatinases By Samima Khatun, Sk. Abdul Amin, Suvankar Banerjee, Shovanlal Gayen, and Tarun Jha

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Modeling Inhibitors of Matrix Metalloproteinases（QSAR in Environmental and Health Sciences） 基质金属蛋白酶的模拟抑制剂 医学生物化学

Modeling Inhibitors of Matrix Metalloproteinases（QSAR in Environmental and Health Sciences）

基质金属蛋白酶的模拟抑制剂
医学生物化学