Biologically Active Small Molecules

图书简介

Biologically Active Small Molecules: Modern Applications and Therapeutic Perspectives focuses on small molecules as active pharmacological agents, their pharmacotherapeutically active properties, new approaches in drug discovery using small molecules, and biopharmaceutic approaches for low molecular weight ligands.Molecules of low mass play a pivotal role in pharmacology because they exhibit multifarious pharmacological effects. Small molecules have become universally popular due to their simple chemistry, easy separation techniques, versatile acceptance for computational studies, large number of places for the substitution of active chemical moieties by well-established synthetic routes with less effort, better quality attributes, and ability to demonstrate numerous biological activities.This book provides a multidisciplinary approach that delivers the most updated knowledge and advances of some newly developed therapeutically active low molecular weight compounds. It includes chapters that present up-to-date and concise content on the classification, structures, chemical syntheses, medicinal chemistry, pharmacology, biochemical pathways, mechanism of actions, side effects, and adverse effects of small molecule drug discovery. The book covers a broad area by highlighting the advances of inter- and multidisciplinary fields of medicine, chemical sciences, and pharmaceuticals. The flowcharts, figures, illustrations, and diagrams provide important information and will be of great interest for readers.

PART I: Small Molecules as Active Pharmacological Agents 1. Bedaquiline: The New Antituberculosis Drug on the Horizon Gyanshankar P. Mishra 2. Plant-Derived Natural Products as Antiglycating Agents Mobashshera Tariq and Ahmad Ali 3. Perspectives of Chalcone-Based Nf-¿ß Inhibitors as Anti-Inflammatory Agents Debarshi Kar Mahapatra, Vivek Asati, and Sanjay Kumar Bharti 4. Coronaviruses: Molecular Modeling and Docking Studies of Potential Drug Candidates Showing Anti-Covid-19 Activity Sefa Celik, et al. PART II: Pharmacotherapeutically Active Classes 5. Perspectives on Local Anesthetics in Medicine T. N. V. Ganesh Kumar 6. Pharmacotherapeutic Perspectives on Adrenergic Agonists Ginpreet Kaur, et al. 7. Therapeutic Perspectives of Adrenergic Antagonists Erica Sequeira, et al. 8. Skeletal Muscle Relaxants: Concepts and Developments Erica Sequeira, Ginpreet Kaur, and Upendra Nagaich 9. Nonsteroidal Anti-Inflammatory Drugs: Concepts and Innovations Upendra Nagaich and Vandana Chaudhary PART III: Modern Approaches in Small Molecule Drug Discovery 10. Biological Databases: Tool for Low Molecular Weight Ligand Discovery Process Santosh S. Chhajed, et al. 11. High-Throughput Screening Technique: Role in the Drug Discovery of Low Molecular Weight Ligands Santosh S. Chhajed and Parag A. Pathade 12. Homology Modeling: Applications in the Low Molecular Weight Ligand Designing Santosh S. Chhajed, et al. PART IV: Biopharmaceutics Approaches for Low Molecular Weight Ligands 13. Drug Metabolism: Detoxification and Xenobiotic Biotransformation Jayakumar Surendradoss, Alice Varg

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Biologically Active Small Molecules 生物活性小分子：现代应用与治疗展望 药物化学

Biologically Active Small Molecules

生物活性小分子：现代应用与治疗展望
药物化学