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PART I Principles of Immune Response 1 The Human Immune Response 2 Organization of the Immune Systemt 3 Innate Immunity 4 Antigen Receptor Genes, Gene Products, and Co-Receptors 5 The Major Histocompatibility Complex 6 Antigens and Antigen Presentation 7 B-Cell Development and Differentiationk 8 Immunoglobulin Function 9 T-Cell Development 10 T-Cell Activation and Tolerance 11 Helper T-Cell Subsets and Control of the Inflammatory Response 12 Cytotoxic T Lymphocytes and Natural Killer Cells 13 Regulatory Immune Cells 14 Cytokines and Cytokine Receptors 15 Chemokines and Chemokine Receptors 16 Lymphocyte Adhesion and Trafficking 17 Death Pathways and Immunogenicity PART II Fundamentals of Host-Environmental Interactions 18 Human Genomics in Immunology 19 Regulatory RNA in Immunologic Diseases 20 Immunometabolism 21 Immune Deficiencies at the Extremes of Age 22 The Microbiota in Immunity and Inflammation PART III Host Defenses to Infectious Agents 23 Immunology of the Skin 24 Immunology of Mucosal Surfaces 25 Host Defenses to Viruses 26 Host Defenses to Intracellular Bacteria 27 Host Defenses to Extracellular Bacteria 28 Host Defenses to Fungi 29 Host Defenses to Protozoa 30 Host Defenses to Helminth Infection 31 Emerging Pandemic Infectious Disease Threats PART IV Immune Deficiency and Immune Regulatory Disorders 32 Approach to the Evaluation of the Patient With Suspected Immunodeficiency 33 Primary Antibody Deficiencies 34 Primary T-Cell Immunodeficiencies 35 Genetic Disorders of Interferons-, Interleukin-17,Interleukin-18, and Nuclear Factor-?B-Mediated Immunity 36 Hemophagocytic Lymphohistiocytosis 37 Autoinflammatory Syndromes 38 Immune Regulatory Disorders 39 Neutrophils and Neutrophil Disorders 40 Complement and Complement Disorders 41 Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome 42 Autoantibody-Mediated Phenocopies of Primary Immunodeficiency Diseases PART V Allergic Diseases 43 Allergic Airway Diseases 44 Mast Cells and Mast Cell Disorders 45 Eosinophils and Eosinophilic Disorders 46 Urticaria, Angioedema, and Anaphylaxis 47 Allergic Reactions to Stinging and Biting Insects 48 Atopic and Contact Dermatitis 49 Food Allergy 50 Drug Hypersensitivity PART VI Systemic Immune Diseases 51 Mechanisms of Autoimmunity 52 Systemic Lupus Erythematosus 53 Rheumatoid Arthritis 54 Juvenile Idiopathic Arthritis 55 Sjoegren’s Syndrome 56 Scleroderma-Systemic Sclerosis 57 Inflammatory Muscle Diseases 58 Spondyloarthritis 59 Small- and Medium-Vessel Primary Vasculitis 60 Large Vessel Vasculitides 61 Antiphospholipid Syndrome PART VII Organ-Specific Inflammatory Disease 62 Immunohematologic Disorders 63 Bullous Diseases of the Skin and Mucous Membranes 64 Immunology of Psoriasis 65 Myasthenia Gravis 66 Multiple Sclerosis 67 Autoimmune Peripheral Neuropathies 68 Immunologic Renal Diseases 69 Immunologic Mechanisms of Atherosclerosis and Myocarditis 70 Autoimmune Thyroid Diseases 71 Type 1 Diabetes 72 Immunologic Lung Diseases 73 Chronic Obstructive Pulmonary Disease and Emphysema 74 Immunologic Ocular Disease 75 Immunologic Diseases of the Gastrointestinal Tract 76 Inflammatory Hepatobiliary Diseases PART VIII Immunology and Immunotherapy of Neoplasia 77 Lymphoid Leukemias 78 Lymphomas 79 Monoclonal Gammopathies 80 Immune Responses to Solid Tumors and Immune Checkpoint Therapy 81 CAR T-Cell Therapy PART IX Medical Management of Immunological Diseases 82 Immunoglobulin Therapy: Replacement and Immunomodulation 83 Glucocorticoids 84 Immunomodulating Drugs 85 Protein Kinase Antagonists 86 Biologic Response Modifiers 87 Vaccines 88 Allergen Immunotherapy for Allergic Diseases PART X Transplantation 89 Solid Organ Transplantation: Rejection, Immunosuppression, and Tolerance 90 Allogeneic Transplantation for Immunodeficiency 91 Gene Therapy for Primary Immune Deficiency Diseases 92 Hematopoietic Stem Cell Transplantation for Malignant Diseases PART XI Diagnostic Immunology 93 Flow Cytometry 94 Assessment of Functional Immune Responses in Lymphocytes 95 Assessment of Neutrophil Function 96 Assessment of Human Allergic Diseases Appendix 1: Selected CD Molecules and Their Characteristics Appendix 2: Laboratory Reference Values Index

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