图书简介

Preface; 1. Discovery and Chemical Development of Suvorexant - A Dual Orexin Antagonist for Sleep Disorder; 2. Discovery of Novel Protein Fucosylation Inhibitors and Development of a Manufacturing Process To Prepare Inhibitor 6,6,6-Trifluorofucose; 3. Development of Hsp90 Inhibitors for the Treatment of HER-2 Positive Solid Cancers; 4. Discovery of the Novel Oxadiazole-Containing 5-Lipoxygenase Activating Protein (FLAP) Inhibitor BI 665915; 5. Development of an Efficient Asymmetric Synthesis of the Chiral Quaternary 5-Lipoxygenase Activating Protein Inhibitor; 6. The Discovery and Process Chemistry Development of GDC-0084, a Brain Penetrating Inhibitor of PI3K and mTOR; 7. Discovery and Development of Doravirine: An Investigational Next Generation Non-Nucleside Reverse Transcriptase Inhibitor (NNRTI) for the Treatment of HIV; 8. The Discovery of Dacomitinib, a Potent Irreversible EGFR Inhibitor; 9. Early and Late Stage Process Development for the Manufacture of Dacomitinib; 10. Discovery and Development of the Natural Product Derivative SPI-1865 as a Gamma Secretase Modulator for Alzheimer’s Disease: Part I; 11. Discovery and Development of the Natural Product Derivative SPI-1865 as a Gamma Secretase Modulator for Alzheimer’s Disease; 12. Telaprevir: From Drug Discovery to the Manufacture of Drug Substance; Editors’ Biographies; Indexes

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