Mosquito Gene Drives and the Malaria Eradication Agenda

图书简介

Malaria is one of most serious infectious diseases today and has afflicted humankind for thousands of years. A significant number of people still die from this mosquito-borne disease, despite the use of various malaria prevention and control methods over hundreds of years and more than a century of coordinated global control efforts using modern tools, together with research into and development of new strategies for prevention, diagnosis, and disease treatment. Genetic approaches that focus on the vector mosquitoes to prevent malaria parasite transmission have been considered for many decades. Genetic control strategies received a significant boost with the successful development of gene drive systems, genetic methods for rapidly spreading beneficial genes and phenotypes through mosquito populations. This book reviews some concepts of gene drive systems and describes pioneering applications to control mosquito populations and prevent parasite transmission.

SECTION I THE MALARIA CHALLENGE 1. Current Scenario of Malaria and the Transformative Power of Gene Drive-Based Technologies George Dimopoulos SECTION II MOSQUITO GENETIC MANIPULATION FOR MALARIA 2. Transgenesis and Paratransgenesis for the Control of Malaria Sibao Wang and Marcelo Jacobs-Lorena 3. Gene Drives for Anopheles Mosquitoes Jackson Champer 4. Gene Drive Applications for Malaria Control Vanessa Macias and Anthony James SECTION III GENE DRIVE MOSQUITO TRIALS 5. Large Cage Trials of Gene Drive Mosquitoes: Does Size Matter? Mark Q. Benedict 6. Field Trial Site Selection for Mosquitoes with Gene Drive: Geographic, Ecological, and Population Genetic Considerations Gregory C. Lanzaro et al. 7. Modeling Priorities as Gene Drive Mosquito Projects Transition from Lab to Field John M. Marshall and Ace R. North SECTION IV RISK ASSESSMENT AND COMMUNITY ENGAGEMENT 8. Probabilistic Ecological Risk Assessment: An Overview of the Process Keith R. Hayes, Geoffrey R. Hosack, and Adrien Ickowicz 9. Community Engagement and Mosquito Gene Drives Ana Kormos SECTION V POLICY, REGULATORY, AND ETHICAL CONSIDERATIONS 10. Review of International Regulatory Instruments and Processes Felicity Keiper and Ana Atanassova 11. Gene Drive Mosquitoes: Ethical and Political Considerations Daniel Edward Callies and Athmeya Jayaram

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Mosquito Gene Drives and the Malaria Eradication Agenda 蚊子基因驱动与疟疾根除议程 动物学

Mosquito Gene Drives and the Malaria Eradication Agenda

蚊子基因驱动与疟疾根除议程
动物学