图书简介
Structure and Intrinsic Disorder in Enzymology offers a direct, yet comprehensive presentation of the fundamental concepts, characteristics and functions of intrinsically disordered enzymes, along with valuable notes and technical insights powering new research in this emerging field. Here, more than twenty international experts examine protein flexibility and cryo-enzymology, hierarchies of intrinsic disorder, methods for measurement of disorder in proteins, bioinformatics tools for predictions of structure, disorder and function, protein promiscuity, protein moonlighting, globular enzymes, intrinsic disorder and allosteric regulation, protein crowding, intrinsic disorder in post-translational, and much more. Chapters also review methods for study, as well as evolving technology to support new research across academic, industrial and pharmaceutical labs.
1. Enzymology: Early insights. M N Gupta and Vladimir N. Uversky 2. Deep mutational scanning to probe specificity determinants. Raghavan Varadarajan 3. Protein flexibility and cryo-enzymology: The trade-off between stability andcatalytic rates Vladimir N. Uversky and Munishwar Gupta 4. Thermodynamic Perspective of Protein Disorder and Phase Separation: Model Systems B. Montgomery Pettitt Pettitt 5. Structure and disorder: Protein functions depend on this new binary transforming lock-and-key into structure-function continuum Vladimir N. Uversky and M N Gupta 6. Methods for measuring structural disorder in proteins Sonia Longhi 7. Prediction of protein structure and intrinsic disorder in the era of deep learning Zsuzsanna Dosztanyi 8. Roles of Intrinsically Disordered Regions in Phosphoinositide 3-Kinase Biocatalysis Vrushank Dave 9. Many faces of protein promiscuity: Not just broad specificity of proteins M N Gupta and Vladimir N. Uversky 10. Role Of Plasticity And Disorder In Protein Moonlighting: Blurring Of Lines Between Biocatalysts And Other Biologically Active Proteins M N Gupta and Vladimir N. Uversky 11. Molten globular enzymes Vladimir N. Uversky 12. Intrinsic disorder and allosteric regulation Zhirong Liu 13. Macromolecular Crowding: How it Affects Protein Structure, Disorder, and Catalysis M N Gupta and Vladimir N. Uversky 14. Intrinsic disorder and post-translational modifications: An evolutionary perspective Paul M. Harrison 15. The roles of prion-like domains in amyloid formation, phase separation, and solubility Eric D. Ross 16. IDPRs of membrane proteins influence membrane curvature Jeanne Stachowiak 17. How binding to surfaces affects disorder. Diego Masone
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