Computational Modeling of Signaling Networks

图书简介

This volume focuses on the computational modeling of cell signaling networks and the application of these models and model-based analysis to systems and personalized medicine. Chapters guide readers through various modeling approaches for signaling networks, new methods and techniques that facilitate model development and analysis, and new applications of signaling network modeling towards systems and personalized treatment of cancer. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and methods, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Computational Modeling of Signaling Networks aims to benefit a wide spectrum of readers including researchers from the biological as well as computational systems biology communities.

Design Principles Underlying Robust Adaptation of Complex Biochemical Networks.- High-dimensional Dynamic Analysis of Biochemical Network Dynamics using pyDYVIPAC.- A Practical Guide for the Efficient Formulation and Calibration of Large, Energy Rule-Based Models of Cellular Signal Transduction.- Systems Biology: Identifiability analysis and parameter identification via systems-biology informed neural networks.- A Practical Guide to Reproducible Modeling for Biochemical Networks.- Integrating Multi-omics Data to Construct Reliable Interconnected Models of Signaling, Gene Regulatory and Metabolic Pathways.- Efficient Quantification of Extrinsic Fluctuations via Stochastic Simulations.- Meta-Dynamic Network Modelling for Biochemical Networks.- Rapid Particle-based Cell Signalling Simulations with the FLAME-accelerated Signalling Tool (FaST) and GPUs.- Modelling Cellular Signalling Variability Based on Single-cell Data: the TGFβ-SMAD Signaling Pathway.- Quantitative Imaging Analysis of NF-κB for Mathematical Modelling Applications.- Resolving Crosstalk between Signaling Pathways using Mathematical Modeling and Time-resolved Single-cell Data.- Live-cell Sender-Receiver Co-cultures for Quantitative Measurement of Paracrine Signaling Dynamics, Gene Expression, and Drug Response.- Application of Optogenetics to Probe the Signaling Dynamics of Cell Fate Decision Making.- Computational Random Mutagenesis to Investigate RAS Mutant Signaling.- Mathematically Modeling the Effect of Endocrine and CDK4/6 Inhibitor Therapies on Breast Cancer Cells.- SynDISCO: a mechanistic modelling-based framework for predictive prioritisation of synergistic drug combinations directed at cell signalling networks.

Trade Policy 买家须知

关于产品：
● 正版保障：本网站隶属于中国国际图书贸易集团公司，确保所有图书都是100%正版。
● 环保纸张：进口图书大多使用的都是环保轻型张，颜色偏黄，重量比较轻。
● 毛边版：即书翻页的地方，故意做成了参差不齐的样子，一般为精装版，更具收藏价值。
关于退换货：
由于预订产品的特殊性，采购订单正式发订后，买方不得无故取消全部或部分产品的订购。
由于进口图书的特殊性，发生以下情况的，请直接拒收货物，由快递返回：
● 外包装破损/发错货/少发货/图书外观破损/图书配件不全（例如：光盘等）
并请在工作日通过电话400-008-1110联系我们。
签收后，如发生以下情况，请在签收后的5个工作日内联系客服办理退换货：
● 缺页/错页/错印/脱线
关于发货时间：
一般情况下：
●【现货】下单后48小时内由北京（库房）发出快递。
●【预订】【预售】下单后国外发货，到货时间预计5-8周左右，店铺默认中通快递，如需顺丰快递邮费到付。
● 需要开具发票的客户，发货时间可能在上述基础上再延后1-2个工作日（紧急发票需求，请联系010-68433105/3213）；
● 如遇其他特殊原因，对发货时间有影响的，我们会第一时间在网站公告，敬请留意。
关于到货时间：
由于进口图书入境入库后，都是委托第三方快递发货，所以我们只能保证在规定时间内发出，但无法为您保证确切的到货时间。
● 主要城市一般2-4天
● 偏远地区一般4-7天
关于接听咨询电话的时间：
010-68433105/3213正常接听咨询电话的时间为：周一至周五上午8：30～下午5：00，周六、日及法定节假日休息，将无法接听来电，敬请谅解。
其它时间您也可以通过邮件联系我们：customer@readgo.cn,工作日会优先处理。
关于快递：
● 已付款订单：主要由中通、宅急送负责派送，订单进度查询请拨打010-68433105/3213。

Computational Modeling of Signaling Networks（Methods in Molecular Biology） 信令网络的计算建模 生物数学

Computational Modeling of Signaling Networks（Methods in Molecular Biology）

信令网络的计算建模
生物数学