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Section I; CNS Demyelinating Disease (Cases 1-21); Case 1 A Woman With Subacute Painful Vision Loss; Jiraporn Jitprapaikulsan, MD, M. Tariq Bhatti, MD, Eric R. Eggenberger, DO, and Marie D. Acierno, MD; Case 2 Rapidly Progressive Numbness and Weakness After Soft-Tissue Abscess; Elia Sechi, MD, and Dean M. Wingerchuk, MD; Case 3 Weakness With Neck Flexion; Brian G. Weinshenker, MD; Case 4 New-Onset Right-Sided Numbness and Double Vision; W. Oliver Tobin, MB, BCh, BAO, PhD; Case 5 Progressive Left Lower Extremity Weakness and Thoracic Spinal Cord Lesion; B. Mark Keegan, MD; Case 6 Progressive Spasticity With a Single Magnetic Resonance Imaging Lesion; Samantha A. Banks, MD, and Eoin P. Flanagan, MB, BCh; Case 7 Fluctuating Vision Loss, Seizures, and Left Parieto-Occipital Mass; Alicja Kalinowska-Lyszczarz, MD, PhD, W. Oliver Tobin, MB, BCh, BAO, PhD, Yong Guo, MD, PhD, and Claudia F. Lucchinetti, MD; Case 8 Diffuse Pain and Abnormal Brain MRI Findings; Andrew McKeon, MB, BCh, MD; Case 9 Lesions Found by Chance; Dean M. Wingerchuk, MD; Case 10 Encephalopathy and Quadriparesis After an Upper Respiratory Tract Infection; A. Sebastian Lopez Chiriboga, MD; Case 11 Severe Monocular Vision Loss Followed by Gait Difficulty; Brian G. Weinshenker, MD; Case 12 Multiple Sclerosis and Cognitive Impairment; Cristina Valencia-Sanchez, MD, PhD, and Jonathan L. Carter, MD; Case 13 New-Onset Gait Difficulty With Kappa Free Light Chains in Cerebrospinal Fluid; Maria Alice V. Willrich, PhD, and Ruba S. Saadeh; Case 14 A Girl With Back Pain, Paresthesias, and Painful Vision Loss; Cecilia Zivelonghi, MD, and Andrew McKeon, MB, BCh, MD; Case 15 A Septuagenarian With Progressive Hemiparesis; Roman Kassa, MD, and B. Mark Keegan, MD; Case 16 Recurrent Demyelinating Episodes; I. Vanessa Marin Collazo, MD; Case 17 Breakthrough Disease While on Multiple Sclerosis Immunomodulatory Therapy; Jonathan L. Carter, MD; Case 18 Highly Active Multiple Sclerosis; Roman Kassa, MD, and W. Oliver Tobin, MB, BCh, BAO, PhD; Case 19 Progressive Gait Difficulties; I. Vanessa Marin Collazo, MD; Case 20 Progressive Cerebellar Ataxia After Natalizumab Treatment; Michel Toledano, MD; Case 21 Weakness and Dysarthria After Radiosurgery; Andrew McKeon, MB, ChB, MD; Section II; Autoimmune Neurologic Disorders (Cases 22-52); Case 22 Fatigue, Blurry Vision, and Swollen Optic Nerves; Marie D. Acierno, MD, M. Tariq Bhatti, MD, John J. Chen, MD, PhD, and Eric R. Eggenberger, DO; Case 23 Progressive, Symmetrical, Painless Visual Loss in an Elderly Woman; Eric R. Eggenberger, DO, Marie D. Acierno, MD, M. Tariq Bhatti, MD, and John J. Chen, MD, PhD; Case 24 Personality Changes, Cognitive Decline, and Jerking Movements; A. Sebastian Lopez Chiriboga, MD; Case 25 Rapidly Progressive Memory Loss, Mood Change, Mutism, and Abnormal Movements; Shailee S. Shah, MD, and Marie F. Grill, MD; Case 26 Behavioral and Cognitive Changes Followed by Coma; Anastasia Zekeridou, MD, PhD; Case 27 Episodic Hemiparesis, Cognitive Decline, and Seizures in a Woman With Pernicious Anemia; Cristina Valencia-Sanchez, MD, PhD, and Andrew McKeon, MB, BCh, MD; Case 28 Rapidly Progressive Dementia and Thyroid Antibodies; Amy C. Kunchok, MBBS, MMED, and Eoin P. Flanagan, MB, BCh; Case 29 Goosebumps and Memory Loss; Jeffrey W. Britton, MD, Bhavya Narapureddy, MBBS, and Divyanshu Dubey, MBBS; Case 30 A Patient With Headache and Progressive Tremor; Anastasia Zekeridou, MD; ; Case 31 A Man With Flulike Symptoms and Hemorrhagic Brain Lesions; Michel Toledano, MD; Case 32 Hearing Loss, Imbalance, and Diplopia in a 44-Year-Old Man; Michelle F. Devine, MD, Divyanshu Dubey, MBBS, and Sean J. Pittock, MD; Case 33 Chorea, Ataxia, and Disturbed Sleep; John C. Feemster, and Erik K. St. Louis, MD, MS; Case 34 Rapidly Progressive Gait and Coordination Difficulties; Andrew McKeon, MB, BCh, MD; Case 35 Dancelike Movements in a Patient With a History of Rash; Andrew McKeon, MB, BCh, MD; Case 36 Body Spasms in a Woman With Thyroid Disease; Andrew McKeon, MB, BCh, MD; Case 37 Stiffness, Spasms, and Frequent Falls in a 41-Year-Old Man; Michelle Devine, MD, and A. Sebastian Lopez Chiriboga, MD; Case 38 Rapid-Onset Weakness and Numbness in a Patient With Systemic Lupus Erythematosus; Floranne C. Ernste, MD; Case 39 Progressive Quadriparesis and Cancer; Elia Sechi, MD, and Eoin P. Flanagan, MB, BCh; Case 40 Progressive Numbness, Burning Pain, Imbalance, and Dryness; Shahar Shelly, MD, and Divyanshu Dubey, MBBS; Case 41 Ascending Painful Paresthesias, Progressive Ataxia, and Bilateral Foot Drop; Rocio Vazquez Do Campo, MD, and Divyanshu Dubey, MBBS; Case 42 Painless, Symmetric, Ascending Weakness and Sensory Loss; Christopher J. Klein, MD; Case 43 Difficult-to-Treat Polyradiculoneuropathy; Marcus V. R. Pinto, MD, MS, and P. James B. Dyck, MD; Case 44 Autoimmune Peripheral Nervous System Hyperexcitability; Christopher J. Klein, MD; Case 45 Orthostatism, Constipation, and Early Satiety; Kamal Shouman, MD, and Eduardo E. Benarroch, MD; Case 46 Constipation and Syncope; Michelle F. Devine, MD, and Sean J. Pittock, MD; Case 47 Bulbar-Predominant Weakness; Jennifer A. Tracy, MD, and Vanda A. Lennon, MD, PhD; Case 48 Difficulty Climbing the Stairs; Anastasia Zekeridou, MD, PhD, and Vanda A. Lennon, MD, PhD; Case 49 Rapidly Progressive Proximal Weakness; Teerin Liewluck, MD, and Margherita Milone, MD, PhD; Case 50 Progressive Weakness and Rash; Margherita Milone, MD, PhD, and Teerin Liewluck, MD; Case 51 Restlessness After Cancer Diagnosis and Treatment; Anastasia Zekeridou, MD, PhD; Case 52 Sudden Onset of Diplopia and a Skeletal Muscle Antibody; John R. Mills, PhD; Section III; Other Inflammatory CNS Disorders and Neuroimmunologic Mimics (Cases 53-83); Case 53 Diplopia, Orbital Pain, and Vision Loss in a Middle-Aged Woman; Lauren M. Webb, and Eoin P. Flanagan, MB, BCh; Case 54 A Young Man With Visual Field Loss, Decreased Hearing, and Confusion; M. Tariq Bhatti, MD, Eric R. Eggenberger, DO, Marie D. Acierno, MD, and John J. Chen, MD, PhD; Case 55 A Woman With Progressive Gait Difficulty and White Matter Abnormalities; Adrian Budhram, MD, and Ralitza H. Gavrilova, MD; Case 56 Progressive Asymmetrical Limb Impairment and Cognitive Decline With Leukoencephalopathy; B. Mark Keegan, MD; Case 57 A Woman With Fever, Confusion, and Seizures; Michel Toledano, MD; Case 58 Encephalopathy With Alternating Hemispheric MRI Abnormalities; Andrew McKeon, MB, BCh, MD; Case 59 Rapid-Onset Hemibody Sensory Loss, Incoordination, and Muscle Jerking; Andrew McKeon, MB, BCh, MD, and Nicholas L. Zalewski, MD; Case 60 A History of Sarcoidosis and a New Brain Lesion; Andrew McKeon, MB, BCh, MD, and Julie E. Hammack, MD; Case 61 Headache and Hemiparesis in Middle Age; Catalina Sanchez Alvarez, MD, and Kenneth J. Warrington, MD; Case 62 Subacute Cognitive Decline in an 86-Year-Old Woman With Prior Lobar Intracerebral Hemorrhage; Stephen W. English Jr, MD, MBA, and James P. Klaas, MD; Case 63 A 75-Year-Old Man With 5 Days of Progressive Gait Difficulties and Confusion; Julie E. Hammack, MD; Case 64 Night Sweats and Paraparesis; David N. Abarbanel, MD, and Ivan D. Carabenciov, MD; Case 65 A Woman With Headaches and a Tumefactive Brain Lesion; Andrew McKeon, MB, BCh, MD; Case 66 Behavioral Change, Seizures, and Temporal Lobe Lesion; Stuart J. McCarter, MD, and Andrew McKeon, MB, BCh, MD; Case 67 A Young Woman With Vessel Dissection and Brainstem Lesions; Burcu Zeydan, MD, and Orhun H. Kantarci, MD; Case 68 Headache, Uveitis, and Leptomeningeal Enhancement; Orhun H. Kantarci, MD; Case 69 Weakness and Punctate Enhancement; W. Oliver Tobin, MB, BCh, BAO, PhD; Case 70 Bilateral Paresthesias in Crohn Disease; Amy C. Kunchok, MBBS, and Andrew McKeon, MB, BCh, MD; Case 71 Seizures and Enhancing Brain Lesions; Josephe Archie Honorat, MD, PhD, and Andrew McKeon, MB, BCh, MD; Case 72 A Man With Recurrent Headache and Focal Neurologic Deficits; Jaclyn R. Duvall, MD, and Jerry W. Swanson, MD, MHPE; Case 73 Headache, Radicular Pain, and Enhancing Lesions; W. Oliver Tobin, MB, BCh, BAO, PhD; Case 74 Seizures 3 Months After Endarterectomy; Andrew McKeon, MB, BCh, MD, and Robert D. Brown Jr, MD, MPH; Case 75 Progressive Bilateral Arm Pain, Gait Disturbance, Constipation, and Urinary Retention; Ivan D. Carabenciov, MD, and Michael W. Ruff, MD; Case 76 A Woman With Subacute Numbness of the Trunk, Arms, and Legs; Eoin P. Flanagan, MB, BCh; Case 77 A Septuagenarian With Progressive Lower Extremity Weakness and Pain; Nicholas L. Zalewski, MD; Case 78 Acute Quadriparesis in a Smoker; Nicholas L. Zalewski, MD; Case 79 A 25-Year-Old Man With Recurrent Back Pain and Rapid-Onset Paraplegia; Nicholas L. Zalewski, MD; Case 80 Progressive Myelopathy After Neck Pain; Eoin P. Flanagan, MB, BCh; Case 81 Progressive Imbalance and Visual Impairment in a Patient With Diabetes; Neeraj Kumar, MD; Case 82 Progressive Myelopathy After Spine Surgery; Andrew McKeon, MB, BCh, MD, and Nicholas L. Zalewski, MD; Case 83 Altered Mental Status During the COVID-19 Pandemic; Sara Mariotto, MD, Silvia Bozzetti, Maria Elena De Rui, Fulvia Mazzaferri, Andrew McKeon, MB, BCh, MD, and Sergio Ferrari; Section IV; Questions and Answers; Section I: Questions, Answers, Suggested Reading; Section II: Questions, Answers, Suggested Reading; Section III: Questions, Answers, Suggested Reading $ $ https://global.oup.com/academic/product/9780197583425 $ http://ukcatalogue.oup.com/images/en_US/covers/large/9780197583425_450.jpg $ $

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