Neurodegenerative Diseases:Unifying Principles

Neurodegenerative Diseases:Unifying Principles

神经退行性疾病：统一原则
精神病学

售价：

发货周期：预计5-7周发货

作者

Cummings, Jeffrey L.; Pillai, Jagan A.

出版社

Oxford University Press

出版时间

2016年12月08日

装帧

精装

ＩＳＢＮ

9780190233563

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页码

360

开本

254x178mm

语种

英文

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暂无评分

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图书简介

Neurodegenerative Diseases: Unifying Principles is the result of a conceptual revolution over the last decade in our understanding of neurodegenerative diseases as sharing unifying features. There is an increasing appreciation of the common biological and pathological features across seemingly varied neurodegenerative diseases that entail protein misfolding dysfunction and its consequences over time. Providing an overview of this conceptual change is the main theme for the book. Conventional approach emphasize the differences among neurodegenerative disorders, here Drs. Cummings and Pillai compile the increasingly compelling evidence that these disorders share many features and that insights in one may be rapidly translated into advances in another. The goal is to accelerate understanding by showing linkages among biological, pathological, can clinical aspects of this class of diseases.

Table of Contents; List of Contributors; 1 Neurodegenerative Diseases: Evolving Unifying Principles; Jeffrey Cummings and Jagan Pillai; 2 Neurodegenerative Diseases as Protein Misfolding Disorders; Tomohiro Nakamura and Stuart A. Lipton; 3 Calcium Hypothesis on Neurodegeneration: The Case of AD and HD; Daniel A. Ryskamp, Elena Popugaeva, and Ilya Bezprozvanny; 4 Neuroinflammation and Neurodegenerative Diseases; Taylor R. Jay, Shane M. Bemiller, Lee E. Neilson, Paul J. Cheng, and Bruce T. Lamb; 5 Prion Paradigm of Human Neurodegenerative Diseases Caused by Protein Misfolding; Jiri Safar; 6 Neuropsychiatric Features Across Neurodegenerative Diseases; Claudia R. Padilla and Mario F. Mendez; 7 Brain Circuits: Pathway for NDD; William Seeley; 8 Fluid Biomarkers Indicative of Neurodegenerative Diseases; Henrik Zetterberg and Jonathan M. Schott; 9 Predementia Disorders: Neurodegenerative Diseases Predecessor States as Unifying Clinical Features; Jagan Pillai; 10 Genetics of Neurodegenerative Diseases: Sporadic and Autosomal Dominant Forms; Lynn M. Bekris and James B. Leverenz; 11 An Epigenetics Perspective on Diseases of the Central Nervous System; Diego Mastroeni; 12 Mitochondrial Changes and Bioenergetics in Neurodegenerative Diseases; Andrew B. Knot and Ella Bossy-Wetzel; 13 Cell Culture and iPS Cells and Neurodegenerative Diseases; Roxana Nat and Andreas Eigentler; 14 Animal Models of Neurodegenerative Diseases; David Baglietto-Vargas, Rahasson R. Ager, Rodrigo Medeiros, and Frank M. LaFerla; 15 Metal-Protein Attenuating Compounds in Neurodegenerative Diseases; Peng Lei, Scott Ayton, and Ashley I. Bush; 16 Disease modifying therapies in neurodegenerative disorders; Janelle Drouin-Ouellet and Roger A. Barker; 17 Immunotherapy for Neurodegenerative Disorders; David Morgan; 18 Clinical Trials and Drug Development in Neurodegenerative Diseases: Unifying Principles; Jeffrey Cummings and Kate Zhong; 19 Conclusions on Neurodegenerative Disorders: Unifying Principles; Jagan Pillai and Jeffrey Cummings; Index

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