图书简介
We have all been hypoxic. Fetal tolerance for intrauterine hypoxia arises from evolutionarily conserved physiological mechanisms, the antecedents of which can be learned from diving mammals or species at high altitudes. Understanding fetal hypoxia leads to understanding the huge physiological shifts of neonatal transition and the dangers of perinatal hypoxia.This comprehensive volume of topical review articles by expert authors addresses the origins of hypoxia tolerance, the impact of oxygen on circulatory transition at birth, and the biochemistry of hypoxia in the pulmonary circuit, as well as the classification, diagnosis, and clinical management of hypoxic respiratory failure and persistent pulmonary hypertension in the term neonate.The goal of Hypoxic Respiratory Failure in the Newborn is to connect our understanding of hypoxia from animals in extreme environments, with how the human fetus handles its hypoxic environment; and why the human newborn suddenly cannot. The book will educate health care professionals on how to care for newborns with hypoxic respiratory failure, including the use of up-to-date diagnostic tools and therapies. It also highlights areas of controversy and ongoing research in hypoxic respiratory failure and pulmonary hypertension of the newborn, including challenging case studies.Key FeaturesExplores evolutionary context and comparative physiology of hypoxia tolerance in the fetus and neonate, from basic research to clinical scenarios Provides guidance to trainees, physicians, and allied health professionals engaged in NICU care; pediatricians, cardiologists, pulmonologists, anesthesiologists, neonatologists, and physiologists to effectively manage infants in hypoxic respiratory failureIncludes case scenarios emphasizing current diagnostic and therapeutic controversies and algorithmic approaches to decipher difficult cli
Table of Contents 1. Introduction Shyamala Dakshinamurti, William K. Milsom, Satyan Lakshminrusimha, Steven H. Abman, Po-Yin Cheung, Patrick McNamara Part 1: The Origins of Hypoxia Tolerance edited by William K. Milsom 2. The Human Fetus and Metabolic Adaptations to Hypoxia Dominique Singer 3. Hypoxia as a Neuroinflammatory Stimulus During Development Peter M. MacFarlane, Allison S. Osborne 4. Human Adaptations to High Altitude Tatum Simonson 5. Fetal Llama Adaptation to Altitude in the Andean Altiplano Anibal J. Llanos, German Ebensperger, Emilio A. Herrera, Roberto V. Reyes, Maria Seron-Ferre 6. Neonates of Burrowing and Hibernating Mammals: Metabolic and Respiratory Adaptations to Hypoxia Yvonne A. Dzal, William K. Milsom 7. Diving Response and Hypoxia in Deep Sea Mammals Allyson Hindle 8. The Phylogeny and Ontogeny of Cardiorespiratory Coupling in Vertebrates and its Relevance to Non-Invasive Monitoring of the Human Fetus Edwin W. Taylor, Harry Gee Part 2: Fetal Hypoxia and Neonatal Transition edited by Satyan Lakshminrusimha 9. Fetal and Neonatal Oxygen Environment Payam Vali, Robin H. Steinhorn, Satyan Lakshminrusimha 10. Fetal Oxygenation During Maternal Hypoxic Illness Fabiana Postolow, Shyamala Dakshinamurti 11. Hemodynamics of the Circulatory Transition Graeme R. Polglase, Martin Kluckow, Andrew W. Gill, Stuart B. Hooper 12. Oxygen During Postnatal Stabilization Maximo Vento, Ola D. Saugstad Part 3: Biology of Hypoxic Respiratory Failure in the Neonate edited by Steven H. Abman 13. Hypoxia and Pulmonary Artery Structure Csaba Galambos, Steven H. Abman 14. Animal Models of PPHN and Vasoconstrictor Signaling in Hypoxia Candice D. Fike, Judy L. Aschner 15. Hypoxia and Endothelial Dysfunction in the Lung Emily Callan, Girija Ganesh Konduri 16. Effects of Hypoxia on Pulmonary Vascular Smooth Muscle Contraction and Relaxation Shyamala Dakshinamurti, Anjali Y. Bhagirath, Robert P. Jankov 17. Cellular Oxygen Sensing, Mitochondrial Oxygen Sensing and Reactive Oxygen Species Jason Boehme, Emin Maltepe 18. Reactive Oxygen Species Signaling in Animal Models of Pulmonary Hypertension Stephen Wedgwood, Satyan Lakshminrusimha, Robin H. Steinhorn 19. Hypoxia, Myocardial Metabolic Adaptation and Right Ventricular Performance Mark K. Friedberg 20. Hypoxic Remodeling of Neonatal Pulmonary Artery and Myocardium Hui Zhang, R. Dale Brown, Jason Williams, Cassidy Delaney, Kurt R. Stenmark 21. Hypoxia-Induced Epigenetic Mechanisms of Pulmonary Hypertension Kurt H. Albertine Part 4: Hypoxia and Collateral Damage edited by Po-Yin Cheung 22. The Effects of Hypoxia Ischemia on the Term Brain, and A Strategic Approach Aravanan Anbu Chakkarapani, Nicola J. Robertson 23. Effects of Hypoxia on Cerebral Perfusion and the Blood-Brain Barrier Divyen K. Shah, W. L. Amelia Lee, David F. Wertheim, Stephen T. Kempley 24. Effects of Hypoxia on Airway, Alveolar Function and Respiration Y.S. Prakash, Christina M. Pabelick, Peter M. MacFarlane 25. Hypoxic Respiratory Failure and the Neonatal Kidney Catherine Morgan, Po-Yin Cheung 26. The Effect of Hypoxia on Intestinal Function Eric B. Ortigoza, Josef Neu 27. Effects of Hypoxia on Perinatal Drug Disposition Karel Allegaert, Anne Smits, Pieter Annaert 28. Anesthetic Considerations for the Neonate with Hypoxic Respiratory Failure M. Ruth Graham Part 5: Diagnosis and Management of Neonatal Hypoxic Respiratory Failure edited by Patrick J. McNamara 29. Epidemiology and Outcomes of Infants with Hypoxemic Respiratory Failure Souvik Mitra, Roberta L. Keller, Prakesh S. Shah 30. Clinical Evaluation of Hypoxic Respiratory Failure Yasser Elsayed, Shyamala Dakshinamurti 31. Diagnosis of Pulmonary Hypertension by Echocardiography Danielle R. Rios, Patrick J. McNamara, Regan E. Giesinger 32. Right Ventricular Performance and Ventricular Interdependence in Hypoxia Afif El Khuffash, Philip T. Levy 33. Ventilation Strategies in Neonatal Hypoxemic Respiratory Failure Bradley A. Yoder, Michelle J. Yang, Nicholas R. Carr, Martin Keszler 34. Pulmonary Hypertension Phenotypes in the Newborn Regan E. Giesinger, John P. Kinsella, Steven H. Abman, Patrick J. McNamara 35. Special Consideration: HRF in Congenital Diaphragmatic Hernia Gabriel Altit, Jason Gien, Nolan DeLeon, Richard Keijzer 36. Special Consideration: Hypoxemic Respiratory Failure Among Patients with Hypoxic Ischemic Encephalopathy Arvind Sehgal, Satyan Lakshminrusimha, Regan E. Giesinger 37. Special Consideration: HRF in the Preterm Michelle Baczynski, Amish Jain, Dany E. Weisz 38. Hypoxemic Respiratory Failure - Neonatal Cases Adrianne Rahde Bischoff, Faith Zhu, Amish Jain, Patrick J. McNamara
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