Smooth Muscle Spontaneous Activity:Physiological and Pathological Modulation

图书简介

This book presents the commonality and heterogeneity of the mechanisms underlying smooth muscle spontaneous activity in various smooth muscle organs and in addition discusses their malfunctions in disease and their potential as novel therapeutic targets. To facilitate understanding, the volume is divided into five parts and covers 16 organs: airways, gastrointestinal tract (phasic muscle, tonic muscle), renal pelvis, ureter, urinary bladder, urethra, corporal tissue, prostate, uterus, oviducts, seminal vesicle, artery, vein, microvasculature, and lymphatic vessels. This structure will help readers to comprehend the most up-to-date information on the similarities and differences in the contractile mechanisms driving various smooth muscles as well as their potential manipulations in particular visceral organ pathologies. The vast advancements in gene, electrical recording, and imaging technologies in this field are also discussed, with review of past achievements and consideration of likely future developments. This book will be of worldwide interest to clinicians, students, and researchers alike.

PART I: Gastrointestinal tract.- Phasic muscle.- Spontaneous electrical activity and rhythmicity in gastrointestinal smooth muscles.- Tonic muscle (Sphincters) .- Generation of tone by gastrointestinal sphincters.- PART II: Urinary tract.- Renal pelvis.- Pacemaker mechanisms driving pyeloureteric peristalsis: modulatory role of interstitial cells.- Ureter.- Excitation-contraction coupling in ureteric smooth muscle: mechanisms driving ureteric peristalsis.- Urinary Bladder.- Spontaneous activity and the urinary bladder.- Urethra.- Spontaneous activity in urethral smooth muscle.- PART III: Reproductive organs.- Corporal tissue.- Ion channels and intracellular calcium signalling in corpus cavernosum.- Prostate.- Generation and regulation of spontaneous contractions in the prostate gland.- Seminal vesicle.- Mucosa-dependent, stretch-sensitive spontaneous activity in seminal vesicle.- Uterus.- The myometrium ? from excitation to contractions and labour.- Oviducts.- Myosalpinx contractions are essential for egg transport along the oviduct and are disrupted in reproductive tract diseases.- PART IV: Blood vessels.- Artery.- Cellular and Ionic Mechanisms of Arterial Vasomotion.- Vein.- Venous Vasomotion.- Microvasculature.- Role of pericytes in the initiation and propagation of spontaneous activity in the microvasculature.- Lymphatic vessels.- Lymphatic vessel pumping.- PART V: Airways.- Regulation of airway smooth muscle contraction in health and disease.

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Smooth Muscle Spontaneous Activity:Physiological and Pathological Modulation（Advances in Experimental Medicine and Biology） 医学生物化学

Smooth Muscle Spontaneous Activity:Physiological and Pathological Modulation（Advances in Experimental Medicine and Biology）
医学生物化学