图书简介
This book gathers a series of pivotal papers on the development of an HIV/AIDS vaccine published in the last two decades. Accompanied by extensive comments putting the material into an up-to-date context, all three parts of the book offer a broad overview of the numerous unsuccessful attempts made in recent years to develop a preventive HIV vaccine. Providing a detailed review and analysis of studies published from 1998 to the present day, it examines the likely reasons for the failure to develop an HIV vaccine despite multi-million dollar investments.
Part I.Immunochemistry.- 1 What is a B cell epitope.- 2 Molecular design versus empirical discovery in peptide-based vaccines. Coming to terms with fuzzy recognition sites and ill-defined structure–function relationships in immunology.- 3 Synthetic Peptide Vaccines and the Search for Neutralization B Cell Epitopes.- 4 Specificity, polyspecificity, and heterospecificity of antibody?antigen recognition.- Part II. Reductionism.- 5 Reductionism and the search for structure–function relationships in antibody molecules.- 6 Reductionism and complexity in molecular biology.- 7 Editorial: Biological complexity emerges from the ashes of genetic reductionism.- 8 The rational design of biological complexity: A deceptive metaphor., 9 Basic research in HIV vaccinology is hampered by reductionist thinking.- 10 Commentary: Basic Research in HIV Vaccinology Is Hampered by Reductionist Thinking.- 11 Nature and Consequences of Biological Reductionism for the Immunological Study of Infectious Diseases., Part III. Vaccinology.- 12 Limitations to the structure?based design of HIV?1 vaccine immunogens.- 13 Two meanings of reverse vaccinology and the empirical nature of vaccine science.- 14 Requirements for empirical immunogenicity trials, rather than structure-based design, for developing an effective HIV vaccine.- 15 Paradigm Changes and the Future of HIV Vaccine Research: A Summary of a Workshop Held in Baltimore on 20 November 2013.- 16 Editorial: Paradigm changes are required in HIV vaccine research.- 17 An outdated notion of antibody specificity is one of the major detrimental assumptions of the structure-based reverse vaccinology paradigm, which prevented it from helping to develop an effective HIV-1 vaccine.- 18 More surprises in the development of an HIV vaccine.- 19 Why Does the Molecular Structure of Broadly Neutralizing Monoclonal Antibodies Isolated from Individuals Infected with HIV-1 not Inform the Rational Design of an HIV-1 Vaccine?.- 20 Old and New Concepts and Strategies in HIV Vaccinology: A Report from a Workshop held in Rome on 17 June 2016.- 21 Structure-Based Reverse Vaccinology Failed in the Case of HIV Because it Disregarded Accepted Immunological Theory.- 22 Immune systems rather than antigenic epitopes elicit and produce protective antibodies against HIV.- 23 Development of a Preventive HIV Vaccine Requires Solving Inverse Problems Which Is Unattainable by Rational Vaccine Design.- 24 Viral species, viral genomes and HIV vaccine design: is the rational design of biological complexity a utopia?
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