图书简介
This book provides the immune oncology (IO) community with a deeper understanding of the scope of the biomarker methods to potentially improve the outcome from immunotherapy. The editors secured the input from experts in the field dedicated to translating scientific research from bench to bedside was submitted. The book provides not only details about the technical, standardization and interpretation aspects of the methods but also introduces the reader to the background information and scientific justification for selected biomarkers and assays. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Status of Immune-oncology: Challenges and Opportunities.- Immunological Targets for Immunotherapy: Inhibitory T Cell Receptors.- Measuring Tumor Mutational Burden Using Whole Exome Sequencing.- Germline Genetics in Immuno-Oncology: From Genome-wide to Targeted Biomarker Strategies.- Detection of Microsatellite Instability Biomarkers via Next-generation Sequencing.- Genetic Instability Markers in Cancer.- Validation of Circulating Tumor DNA Assays for Detection of Metastatic Melanoma.- Techniques Associated with Exosome Isolation for Biomarker Development ? Liquid Biopsies for Ovarian Cancer Detection.- Identifying MicroRNA Pathway Variants as Biomarkers of Patient Selection for Immune Therapy.- Histone Modifications as Biomarkers for Immunotherapy.- Functional Genome Profiling to Understand Cancer Immune Responsiveness.- Using RNA-sequencing to Characterize the Tumor Microenvironment.- Development of Gene Expression Based Biomarkers on the nCounter® Platform for Immuno-Oncology Applications.- The CRISPR System and Cancer Immunotherapy Biomarkers.- HLA Class I Antigen Processing Machinery Defects in Cancer Cells - Frequency, Functional Significance and Clinical Relevance with Special Emphasis on their Role in T cell-based Immunotherapy of Malignant Disease.- High-parameter Immune Profiling with CyTOF.- The Adaptome as Biomarker for Assessing Cancer Immunity and Immunotherapy.- Single Molecule Arrays for Ultrasensitive Detection ofBlood-basedBiomarkers for Immunotherapy.- Single-cell Multiplexed Proteomics on the IsoLight Resolves Cellular Functional Heterogeneity to Reveal Clinical Responses of Cancer Patients to Immunotherapies.- Methods to Detect Immunogenic Cell Death in vivo.- Overview of Tissue Imaging Methods.- Multiplex Immunofluorescence Assays.- Multiplexed Immunohistochemical Consecutive Staining on Single Slide (MICSSS): Multiplexed Chromogenic IHC Assay for High-Dimensional Tissue Analysis.- Cyclic Multiplexed-Immunofluorescence (cmIF), A Highly Multiplexed Method for Single-cell Analysis.- High-Plex Spatially Resolved RNA and Protein Detection using Digital Spatial Profiling: A Technology Designed for Immuno-Oncology Biomarker Discovery and Translational Research.- The InSituPlex® Staining Method for Multiplexed Immunofluorescence Cell Phenotyping and Spatial Profiling of Tumor FFPE Samples.- Microbiome as an Immunological Modifier.- Systems Biology for Multi-Platform Data Integration ? Overview.- Bioinformatics Tools and Resources for Cancer Immunotherapy Study.- Multiplatform Integrative Analysis of Immunogenomic Data for Biomarker Discovery.- Translating Immuno-Oncology Biomarkers to Diagnostic tests: A regulatory Perspective.
Trade Policy 买家须知
- 关于产品:
- ● 正版保障:本网站隶属于中国国际图书贸易集团公司,确保所有图书都是100%正版。
- ● 环保纸张:进口图书大多使用的都是环保轻型张,颜色偏黄,重量比较轻。
- ● 毛边版:即书翻页的地方,故意做成了参差不齐的样子,一般为精装版,更具收藏价值。
关于退换货:
- 由于预订产品的特殊性,采购订单正式发订后,买方不得无故取消全部或部分产品的订购。
- 由于进口图书的特殊性,发生以下情况的,请直接拒收货物,由快递返回:
- ● 外包装破损/发错货/少发货/图书外观破损/图书配件不全(例如:光盘等)
并请在工作日通过电话400-008-1110联系我们。
- 签收后,如发生以下情况,请在签收后的5个工作日内联系客服办理退换货:
- ● 缺页/错页/错印/脱线
关于发货时间:
- 一般情况下:
- ●【现货】 下单后48小时内由北京(库房)发出快递。
- ●【预订】【预售】下单后国外发货,到货时间预计5-8周左右,店铺默认中通快递,如需顺丰快递邮费到付。
- ● 需要开具发票的客户,发货时间可能在上述基础上再延后1-2个工作日(紧急发票需求,请联系010-68433105/3213);
- ● 如遇其他特殊原因,对发货时间有影响的,我们会第一时间在网站公告,敬请留意。
关于到货时间:
- 由于进口图书入境入库后,都是委托第三方快递发货,所以我们只能保证在规定时间内发出,但无法为您保证确切的到货时间。
- ● 主要城市一般2-4天
- ● 偏远地区一般4-7天
关于接听咨询电话的时间:
- 010-68433105/3213正常接听咨询电话的时间为:周一至周五上午8:30~下午5:00,周六、日及法定节假日休息,将无法接听来电,敬请谅解。
- 其它时间您也可以通过邮件联系我们:customer@readgo.cn,工作日会优先处理。
关于快递:
- ● 已付款订单:主要由中通、宅急送负责派送,订单进度查询请拨打010-68433105/3213。
本书暂无推荐
本书暂无推荐