图书简介

Introduction: The Protein Folding Problem: Some of the Myths Associated with the Protein Folding Theories; From Frank and Evans’ Iceberg-Formation Conjecture to the Explanation of the Hydrophobic Effect; From Schellman’s Experiments to Fersht’s Hydrogen Bond Inventory Argument; From Kauzmann’s Conjecture to the Myth that the Hydrophobic Effect is the Dominant Factor in Protein Stability; From Levinthal’s Question to Solving the Levinthal \"Paradox\"; From Anfinsen Hypothesis to the Frenetic Pursuit of the Global Minimum in the Gibbs Energy Landscape; Some Candidates which could Potentially Evolve into New Myths; Appendices: Definition of the Solvation Process and the Corresponding Thermodynamic Quantities; Definition of the Structure of Water and Changes in the Structure Induced by a Solute; Le Chatelier Principle Applied to the Two Structure Model for Water; The Stability Condition for a Chemical Reaction; Solvation Gibbs Energy of Hard Sphere (HS) and the Work of Cavity Formation; Formal Expression for the Thermodynamic Quantities of Solvation of a Non-Polar Solute; The Solvation Entropy and Solvation Energy and Structural Changes in the Solvent; The Solubility of a Simple Solute in Water and Structural Changes Induced in the Solvent; Ben-Naim’s \"Pitfalls: \" Don Quixote’s Windmill; Examples of Gibbs Energy Landscapes and Gibbs Energy Functionals; The Single Minimum of the Gibbs Energy Functional; Non-Additivity of the Gibbs Energy Function; Non-Additivity in Binding Systems; Frustration in Three Dipoles on a Lattice, an Informational Theoretical Approach;

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