图书简介
Osteoporosis is one of the leading causes of morbidity and mortality amongst the elderly. The Osteoporosis Primer provides an excellent introduction that relates the clinical presentation of osteoporosis to its molecular biochemical basis, and reviews therapeutic options. It will be an essential read for all those working on metabolic bone disease.
Preface Janet E. Henderson and David Goltzman; Part I. Molecular and Cellular Environment of Bone: 1. Endochondral bone formation and development in the axial and appendicular skeletaon A. Robin Poole, Sheila Laverty and Fackson Mwale; 2. The role of osteoblasts Jane E. Aubin; 3. Osteoclasts: characteristics and regulation of formation and activity Johan Heersche and Morris F. Manolson; 4. Bone matrix proteins Marc D. McKee and Jaro Sodek; 5. Local regulators of bone turnover Lawrence J. Fraher and Patricia H. Watson; 6. The PTH/PTHrP system and calcium homeostasis Geoffrey N. Hendy; 7. Vitamin D metabolism Marielle Gascon-Barre; 8. Sodium-dependent phosphate transport in kidney, bone and intestine Harriet S. Tenenhouse; Part II. Determinants of Peak Bone Mass: 9. Molecular genetic analysis of growth factor signalling in bone Janet E. Henderson and David Goltzman; 10. Genetic determinants of osteoporosis Milan S. Patel, Laurence A. Rubin and David E. C. Cole; 11. Non-genetic determinants of peak bone mass Velimir Matkovic and John D. Landoll; 12. Bone mineral acquisition during childhood and adolescence: physical exercise as a preventative measure Heather A. McKay and Karim M. Khan; 13. Osteoporosis in children Frank Rauch and Francis H. Glorieux; Part III. Pathophysiology of the Aging Skeleton: 14. Consequences of alterations in bone remodeling Karen Prestwood and Lawrence G. Raisz; 15. The role of parathyroid hormone and hyperparathyroidism in osteoporosis Pierre D’Amour; 16. Senile osteoporosis Patrick M. Doran and Sundeep Khosla; Part IV. Clinical Aspects of Osteoporosis; 17. Epidemiology Jaques Brown; 18. Biochemical markers of bone turnover David Hanley; 19. Radiologic assessment of osteoporosis Jaqueline C. Hodge; 20. Bone mineral density measurements Paul D. Miller and Carol Zapalowski; 21. Hormone replacement therapy Jonathan D. Adachi and Alexandra Papaioannou; 22. Selective estrogen receptor modulators Felicia Cosman and Robert Lindsay; 23. Bisphosphonate therapy of osteoporosis Fred Singer and Payam Minoofar; 24. The action of fluoride on bone Marc D. Grynpas, D. Chachra and H. Limeback; 25. PTH peptides as anabolic agents in bone Anthony B. Hodsman; 26. Vitamin D and Vitamin D analogs as therapeutic agents Richard Kremer.
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