图书简介
As chemical exposures and cancer rates increase worldwide, there is a need for students, researchers, public health professionals, and physicians to understand the mechanisms connecting exposure with human cancer risk. This new book is an essential reference, as well as introduction to the field of chemical carcinogenesis, with particular focus on DNA damage as a critical link between exposure and disease, and emphasis on biomarkers associated with cancer risk in humans. In addition to DNA damage, related topics covered include metabolism of selected chemical carcinogens, exposure-induced epigenetic changes, cancer-associated mutations and reduction of DNA damage and cancer risk by chemoprevention. The book is designed to be a comprehensive guide to basic principles, a teaching tool for academics, and a map for the development of protective mechanisms to reduce human cancer risk.
Key Features:
○ Provide a self-contained textbook in the field of quantum information, from the basic background to more advanced and recent topics
○ The book will contain a large number of exercises, which will be an essential complement to the main text
Importance of DNA Damage in Carcinogen-Associated Human Cancer Risk (Miriam C Poirier); DNA Damage by Tobacco Carcinogens (Stephen S Hecht); Measurement of Polycyclic Aromatic Hydrocarbon-DNA Adducts and Studies of Human Cancer Risk using Antibody-based Methods (Regina M Santella); The Role of Cytochrome P450 Enzymes in Carcinogen Metabolism: Lessons Learned from Studies with Benzo[α]pyrene and Aristolochic Acid (Marie Stiborová, Laura E Wohak and Volker M Arlt); Metal Carcinogenesis and DNA Damage: A Case Study using Hexavalent Chromium (Sandra S Wise and John Pierce Wise, Sr); Aflatoxin Exposure, Human Liver Cancer Risk and Chemoprevention (Thomas W Kensler and John D Groopman); Chemical Carcinogen Exposure, DNA Damage, and Epigenetic Alterations (Kostiantyn Dreval and Igor P Pogribny); Chemical Exposures, DNA Damage, and Human Lung Cancer Risk (Ainsley Weston and Miriam C Poirier); The Future of DNA Damage Analysis as a Component in Elucidation of Human Cancer Risk (David H Phillips); Monitoring DNA Damage Induced by Chemotherapeutic Agents as a Predictor of Clinical Outcome (Soterios A Kyrtopoulos); Antiretroviral Drugs, Genotoxicity and Carcinogenesis (Ofelia A Olivero); Cancer Chemoprevention via Reduction of DNA Damage (Gary D Stoner)
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