Translational Admet for Drug Therapy:Principles, Methods, and Pharmaceutical Applications

药物治疗的平移吸收:原理、方法与药物应用

化学工程基础学科

售   价:
1219.00
发货周期:预计3-5周发货
作      者
出  版 社
出版时间
2015年10月02日
装      帧
精装
ISBN
9781118838273
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页      码
352
开      本
155.6x235mm
语      种
英文
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图书简介
This is a practical and up-to-date book about ADMET for drug therapy. Serving as a handbook for pharmaceutical, biotech, and drug development scientists, it includes methods, applications, data interpretation, and decision-making tactics for optimal drug discovery and development. Chapters address each critical parameter implicated in drug disposition and drug-drug interactions (DDI) along with effective approaches and models used. The first chapters cover principles and tools for ADME, each chapter focusing on one parameter: drug absorption, distribution, metabolism, and excretion. Following those is coverage about DDI and toxicity, discussing mechanisms, regulatory guidance, in vivo preclinical toxicology studies, and drug-induced body organ toxicity. The next section includes chapters on translational tools used in ADMET assessment - such as PBPK / in silico prediction, modelling and simulation, and translational research tools towards individualized medicine and design of clinical investigation in special human populations. Finally, the book emphasizes procedures and documentation for phase I and II clinical studies and regulatory submission guidelines in the United States, Europe, and Asia. All chapters in the book present case studies and examples to demonstrate successful approaches in drug therapy and the integration of in vitro, in vivo, and computational approaches for the design of safe and effective medicines.
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