Epigenetics is the study of both heritable and non-heritable changes in the regulation of gene activity and expression that occur without an alteration in the DNA sequence. This dynamic and rapidly developing discipline is making its impact across the biomedical sciences, in particular in toxicology where epigenetic differences can mean that different individuals respond differently to the same drug or chemical. ? Toxicology and Epigenetics reflects the multidimensional character of this emerging area of toxicology, describing cutting-edge molecular technologies to unravel epigenetic changes, the use of in vivo and in vitro models, as well as the potential use of toxicological epigenetics in regulatory environments. Over two voumes an international team of experts consider the interplay between epigenetics and toxicology in a number of areas, including environmental, nutritional, pharmacological, and computational toxicology, nanomaterials, proteomics and metabolomics, and cancer research. Topics covered include: ? environment, epigenetics and diseases? DNA methylation and toxicogenomics chromatin at the intersection of disease and therapy molecular epigenetic changes caused by environmental pollutants epigenetic mediation of environmental exposures to polycyclic aromatic hydrocarbons epigenomic actions of environmental arsenicals arsenic-induced changes to the epigenome environmental epigenetics, asthma and allergy: our environments molecular footprints miRNAs in human prostate cancer environment, epigenetics and cardiovascular health toxicology, epigenetics and autoimmunity toxicoepigenomics in lupus ocular epigenomics: potential sites of environmental impact in development and disease nuclear RNA silencing and related phenomena in animals epigenetic biomarkers in cancer detection and diagnosis epigenetic histone changes in the toxicologic mode of action of arsenic irreversible effect of diethylstilbestrol on reproductive organs and current approach for epigenetic effects of endocrine disrupting chemicals epigenomics - impact for drug safety sciences archival toxicoepigenetics: molecular analysis of modified dna from preserved tissues in toxicology studies nanoparticles and toxicoepigenomics methods of global epigenomic profiling transcriptomics: applications in epigenetic toxicology carcinogenic metals alter histone tail modifications prediction of epigenetic and stochastic gene expression profiles of late effects after radiation exposure modulation of developmentally regulated gene expression programs through targeting of polycomb and trithorax group proteins chromatin insulators and epigenetic inheritance in health and disease bioinformatics for high-throughput toxico-epigenomics studies computational methods in toxicoepigenomics databases and tools for computational epigenomics interface of epigenetics and carcinogenic risk assessment epigenetic modifications in chemical carcinogenesis application of cancer toxicoepigenomics in identifying high-risk populations ? Toxicology and Epigenetics is an essential insight into the current trends and future directions of research in this rapidly expanding field for investigators, toxicologists, risk assessors and regulators in academia, industry and government.

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