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VOLUME 1; Part 1: Assessment of the patient with renal disease; 1 Aminu K. Bello, Marcello Tonelli, and Kitty J. Jager: Epidemiology of kidney disease; 2 Chris Winearls: Clinical assessment of the patient with renal disease; 3 Chris Winearls: Presentations of renal disease; 4 Chris Winearls: Kidney disease focused history taking; 5 Chris Winearls: Kidney disease focused features on examination; 6 Walter P. Mutter: Urinalysis; 7 Walter P. Mutter: Assessment of renal function; 8 Walter P. Mutter: Tubular function; 9 Michael Weston: Renal radiology: overview; 10 Jeannette Kathrin and Peter Howells: Ionising radiation and radiation protection; 11 Akira Kawashima and Andrew J. LeRoy: Plain radiography, excretion radiography, and contrast radiography; 12 Steven Kennish: Intervention; 13 Toby Wells and Simon Freeman: Ultrasound; 14 Eugene Teoh and Michael Weston: Computed tomography; 15 Kazuhiro Kitajima, Akira Kawashima. and James F Glockner: Magnetic Resonance Imaging; 16 Ramya Dhandapani and Sobhan Vinjamuri: Radioisotopes in diagnostic imaging in nephrology; 17 Jo H.M. Berden and Jack Wetzels: Immunological investigation of the patient with renal disease; 18 Ian Roberts, Phil Mason and Agnes Fogo: The renal biopsy; 19 Richard Haynes, Martin J Landry, William G Herrington, and Colin Baigent: Clinical trials- how and why in nephrology; Part 2: The patient with fluid, electrolyte, and renal tubular disorders; 20 Matthew A. Bailey: An overview of tubular function; 21 Laurent Schild: Sodium transport and balance: A key role for the distal nephron; 22 David Marples and Soren Neilson: Water homeostasis; 23 Alain Doucet and Gilles Crambert: Potassium homeostasis; 24 Carsten Wagner and Olivier Devuyst: Renal acid-base homeostasis; 25 Heini Murer, Juerg Biber, and Carsten Wagner: Phosphate homeostasis; 26 Francesco Trepiccione and Gianni Capasso: Calcium homeostasis; 27 Pascal Houillier: Magnesium homeostasis; 28 Ewout Hoorn and Bob Zietse: Approach to the patient with hyponatraemia; 29 Bob Zietse: Approach to the patient with hypernatraemia; 30 Jean-Marie Krzesinski and Eric P. Cohen: Approach to the patient with oedema; 31 Detlef Bockenhauer and Robert Kleta: Approach to the patient with salt-wasting; 32 Daniel Bichet: Approach to the patient with polyuria; 33 David Ellison and Arohan R. Subramanya: Clinical use of diuretics; 34 Charles Wingo and I. David Weiner: Approach to the patient with hypo-/hyperkalaemia; 35 Mitch Halperin and Kamel Kamel: Approach to the patient with metabolic acidosis or alkalosis; 36 Stephen Walsh: Approach to the patient with renal tubular acidosis; 37 Dennis Jose Joseph and Theresa A. Guise: Approach to the patient with hypercalcaemia; 38 Agnes Linglart and Anne-Sophie Lambert: Approach to the patient with hypocalcaemia; 39 Judith Blaine, Hector Giral-Arnal, Sabina Jelen, and Moshe Levi: Approach to the patient with hypo-/hyperphosphataemia; 40 Martin Konrad and Karl Peter Schlingmann: Approach to the patient with hypomagnesaemia; 41 Detlef Bockenhauer and Robert Kleta: Approach to the patient with renal Fanconi syndrome, glycosuria or aminoaciduria; Part 3: The patient with glomerular disease; 42 Alexander Woywodt and Diana Chiu: The glomerulus and the concept of glomerulonephritis; 43 Marlies Elger and Wilhelm Kriz: The renal glomerulus - the structural basis of ultrafiltration; 44 Jean-Claude Dussaule, Martin Flamant, and Christos Chatziantoniou: Function of the normal glomerulus; 45 Neil Turner: Mechanisms of glomerular injury: overview; 46 John Neary and Neil Turner: The patient with haematuria; 47 John Neary: Loin pain haematuria syndrome; 48 John Neary and Neil Turner: Nutcracker syndrome and phenomenon; 49 Neil Turner: Exercise-related pseudonephritis; 50 Neil Turner and Stewart Cameron: Proteinuria; 51 Neil Turner: Postural proteinuria (Benign orthostatic proteinuria); 52 Premil Rajakrishna, Stewart Cameron and Neil Turner: Nephrotic syndrome; 53 Neil Turner and Premil Rajakrishna: Pathophysiology of oedema in nephrotic syndrome; 54 Patrick Niaudet and Alain Meyrier: Idiopathic nephrotic syndrome: overview; 55 Patrick Niaudet and Alain Meyrier: Minimal change disease: clinical features and diagnosis; 56 Patrick Niaudet and Alain Meyrier: Minimal change disease: treatment and outcome; 57 Patrick Niaudet and Alain Meyrier: Primary focal segmental glomerulosclerosis (FSGS): Clinical features and diagnosis; 58 Patrick Niaudet and Alain Meyrier: Primary focal segmental glomerulosclerosis (FSGS): Treatment and outcome; 59 Patrick Niaudet and Alain Meyrier: Pathogenesis of proteinuria in minimal change disease and FSGS; 60 Daniel Cattran and Heather Reich: Membranous glomerulonephritis: overview; 61 Daniel Cattran and Heather Reich: Membranous glomerulonephritis: clinical features and diagnosis; 62 Daniel Cattran and Heather Reich: Membranous glomerulonephritis: treatment and outcome; 63 Daniel Cattran and Heather Reich: Secondary membranous glomerulonephritis; 64 Daniel Cattran and Heather Reich: Membranous glomerulonephritis: pathogenesis; 65 Kar Nen Lai and Sydney C. W. Tang: Immunoglobulin A nephropathy: overview; 66 Kar Nen Lai and Sydney C. W. Tang: Immunoglobulin A nephropathy: clinical features; 67 Kar Nen Lai and Sydney C. W. Tang: Immunoglobulin A nephropathy: diagnosis; 68 Kar Nen Lai and Sydney C. W. Tang: Immunoglobulin A nephropathy: treatment and outcome; 69 Kar Nen Lai and Sydney C. W. Tang: Immunoglobulin A nephropathy: pathogenesis; 70 Neil Turner: Crescentic (rapidly progressive) glomerulonephritis; 71 Ciao Zhou, Neil Turner, and Ming-hui Zhao: Anti-glomerular basement membrane disease: overview; 72 Ciao Zhou, Neil Turner, and Ming-hui Zhao: Anti-glomerular basement membrane disease: clinical features and diagnosis; 73 Ciao Zhou, Neil Turner, and Ming-hui Zhao: Anti-glomerular basement membrane disease: treatment and outcome; 74 Ciao Zhou, Neil Turner, and Ming-hui Zhao: Antiglomerular basement membrane disease: pathogenesis; 75 Neil Turner: Alport post-transplant antiglomerular basement membrane disease; 76 Bernardo Rodriguez-Iturbe and Mark Haas: Post-infectious glomerulonephritis: overview; 77 Bernardo Rodriguez-Iturbe and Mark Haas: Post streptococcal glomerulonephritis; 78 Bernardo Rodriguez-Iturbe and Mark Haas: Immunoglobulin A dominant post-infectious glomerulonephritis; 79 Bernardo Rodriguez-Iturbe and Mark Haas: Glomerulonephritis associated with endocarditis, deep-seated infections and shunt nephritis; 80 T. Cook and Daniel Gale: Membranoproliferative glomerulonephritis and C3 glomerulopathy; 81 Stephen Korbet, Melvin M.Schwartz, and Edmund J. Lewis: Fibrillary and immunotactoid glomerulopathy; 82 Alexander Woywodt and Diana Chiu: Drug induced and toxic glomerulopathies; Part 4: The patient with interstitial disease; 83 Richard Baker and B.Chir: Acute tubulointerstitial nephritis: overview; 84 Hassan Izzedine and Victor Gueutin: Drug-induced acute tubulointerstitial nephritis; 85 Gregory L. Braden and Benjamin J. Freda: Other toxic acute tubulointerstitial nephritis; 86 Adalbert Schiller, Adrian Covic, and Liviu Segall: Chronic tubulointerstitial nephritis: overview; 87 Hassan Izzedine and Victor Gueutin: Drug-induced chronic tubulointerstitial nephritis; 88 Patrick C D’Haese, Benjamin Vervaet, and A Verhulst: Heavy metals-induced tubulointerstitial nephritis; 89 Refik Gokmen and Graham Lord: Aristolochic acid nephropathy caused by ingestion of herbal medicinal products; 90 Milan Radovic and Adalbert Schiller: Balkan endemic nephropathy; 91 Lisa Phipps and David C. Harris: Radiation nephropathy; 92 D. H. Kang and M. Kanbay: Urate nephropathy; 93 Liviu Segall and Adrian Covic: Immune-mediated tubulointerstitial nephritis; Part 5: The patient with reduced renal function; 94 Ashish Upadyhah, Lesley Inker, and Andrew Levey: Chronic kidney disease: definition, classification, and approach to management; 95 Morgan Grams and Josef Coresh: Chronic kidney disease in the developed world; 96 LuXia Zhang and Haiyan Wang: Chronic kidney disease in developing countries; 97 M. Beaulieu, C. Weber, N. Zalunardo and Adeera Levin: Chronic kidney disease long-term outcomes: progression, death, cardiovascular disease, infections, and hospitalizations; 98 David Goldsmith: Cardiovascular disease and chronic kidney disease: overview; 99 Charles Ferro and Khai Ping Ng: Recommendations for management of high renal risk chronic kidney disease; 100 Teena Tandon and Rajiv Agarwal: Hypertension as a cause of chronic kidney disease: what is the evidence?; 101 Juan Jesus Carrero, Xu Hong, and Bengt Lindholm: Diet and the progression of chronic kidney disease; 102 Alan Jardine and Rajan Patel: Lipid disorders of patients with chronic kidney disease; 103 Stephan R. Orth: Smoking in chronic kidney disease; 104 Edmund Lamb and Finlay MacKenzie: Analytical aspects of measurements and laboratory values in chronic and acute kidney disease; 105 Andrew Williams, Robert Fassett, Erin Howden, and Jeff Coombes: Effect of lifestyle modifications on patients with chronic kidney disease; 106 Naveet Kumar, Peter McCulloch, Heather Henderson, and Beverly D. Cameron: Malnutrition, obesity, and undernutrition in chronic kidney disease; 107 Carmine Zoccali, Francesca Mallamaci, and Davide Bolignano: Left ventricular hypertrophy in chronic kidney disease; 108 Reza Hajhosseini, Kaivan Korvath, and David Goldsmith: Sudden cardiac death in chronic kidney disease; 109 Patrick Biggar, Hansjoerg Rothe, and Markus Ketteler: Epidemiology of calcium, phosphate and PTH disturbances in chronic kidney disease; 110 Juan Jesus Carrero and Peter Stenvinkel: The role of inflammation in chronic kidney disease; 111 John Townend and Charles Ferro: Vascular stiffness in chronic disease - pathophysiology and implications; 112 Nostratoli Vaziri: Oxidative stress and its implications in chronic disease; 113 Thimoteus Speer and Danilo Fliser: Abnormal endothelial vasomotor and secretory function; 114 Neeraj Dhaun and David Webb: Endothelins and their antagonists in chronic kidney disease; 115 Stuart Sprague and Menaka Sarav: Chronic kidney disease-mineral and bone disorder: overview; 116 Paulo Raggi and Luis D’Marco Gascon: Imaging for detection of vascular disease in chronic kidney disease patients; 117 Alexandra Voinescu, Nadia Iqbal and Kevin Martin: Pathophysiology of chronic kidney disease - mineral and bone disorder; 118 Alexandra Voinescu, Kevin Martin, Nadia Iqbal, and David Goldsmith: Management of chronic kidney disease - mineral and bone disorder; 119 Orlando Gutierrez: Fibroblast growth factor 23, klotho, and phosphorus metabolism in chronic kidney disease; 120 Adrian Covic, Mugurel Apetrii, Luminita Voroneanu, and David Goldsmith: Vascular calcification; 121 Alastair Hutchison and Michael L. Picton: Fractures in patients with chronic kidney disease; 122 Stuart Sprague and James Pullman: Spectrum of bone pathologies in chronic kidney disease; 123 Iain Macdougall: Clinical aspects and overview of renal anaemia; 124 Iain Macdougall and Jolanta Malyszko: Erythropoiesis-stimulating agents in chronic kidney disease; 125 Jolanta Malyszko and Iain Macdougall: Iron metabolism in chronic kidney disease; 126 Iain Macdougall: Iron management in renal anaemia; 127 Kaivan Khavandi, Halima Amer, Sarah Withers, and Behdad Afzali: Pleoitropic effects of Vitamin D; 128 Behdad Afzali and Claudia Kemper: Immunity; 129 Fabrizio Fabrizi and Michel Jadoul: The liver and chronic kidney disease; 130 Rishi Goel, Kamal Patel, and Terry Wong: Gastroenterology and renal medicine; 131 Timur A. Galperin, Kieron S. Leslie, and Antonia J. Cronin: Cutaneous manifestations of end-stage renal disease (ESRD); 132 Tomas Agustsson and Paul Carroll: The patient with reduced renal function: endocrinology; 133 Tomas Agustsson and Paul Carroll: Sexual dysfunction; 134 Fred Finkelstein and Susan Finkelstein: Health related quality of life and the patient with chronic kidney disease; 135 Seema Shrivastava, Beverley Hunt, and Tony Dorling: Coagulopathies in chronic kidney disease; 136 Neil Turner: Mechanisms of progression of chronic kidney disese- overview; 137 Jeremy Hughes: Proteinuria as a direct cause of progression; 138 Valerie Luyckx: Nephron numbers and hyperfiltration as drivers of progression; 139 Wilhelm Kriz: Podocyte loss as a common pathway to chronic kidney disease; 140 Jeremy Duffield: Disordered scarring and failure of repair; 141 Raj Thuraisingham and Cormac Breen: Modality selection for renal replacement therapy; 142 Sue Cox and Nicola Thomas: Patient education and involvement in pre-dialysis management; 143 Muh Geot Wong, Bruce A. Cooper, and Carol A. Pollock: Preparation for renal replacement therapy; 144 Karthik Tennankore and Chris Chan: Choices and considerations for in-centre versus home based renal replacement therapy; 145 Aine Burns and Fliss E.M. Murtagh: Conservative care in advanced chronic kidney disease; 146 Katie Vinen, Fliss E.M. Murtagh, and Irene Higginson: Palliative care in end stage renal disease; 147 Bernadette Thomas and Christopher Blagg: Patient selection when resources are limited; 148 Muhammad Magdi Yaqoob: Acidosis in chronic kidney disease; VOLUME 2; Part 6: The patient with another primary diagnosis; 149 Luigi Gnudi, Giorgio Gentile, and Piero Ruggenenti: The patient with diabetes mellitus; 150 Pierre M. Ronco: Kidney involvement in plasma cell dyscrasias; 151 Fabrizio Fabrizi and Patrice Cacoub: The patient with cryoglobulinaemia; 152 Helen J. Lachmann and Giampaolo Merlini: The patient with amyloidosis; 153 Efstathios Kastritis and M. A. Dimopoulos: The patient with myeloma; 154 Dirk R. J. Kuypers and Morie A. Gertz: Light chain deposition disease; 155 Fernardo Fervenza, S. Vincent Raj Kumar, and Sethi Sanjeev: Other consequences from monoclonal immunoglobulins/fragments: Membranoproliferative Glomerulonephritis and Acquired Fanconi Syndrome; 156 Ravi Rajakaria and Muhammad Magdi Yaqoob: The patient with sarcoidosis; 157 David Jayne: The patient with vasculitis- overview; 158 Peter Heeringa and Coen A. Stegeman: The patient with vasculitis: pathogenesis; 159 Alan Salama: The patient with vasculitis: clinical aspects; 160 Lorraine Harper and David Jayne: The patient with vasculitis: treatment and outcome; 161 Johan van der Vlag and Jo H.M. Berden: The patient with systemic lupus erythematosus: overview and pathogenesis; 162 Marie Condon, Philippa Dodd, and Liz Lightstone: The patient with systemic lupus erythematosus: clinical features, investigations, and diagnosis; 163 Frederic Houssiau: The patient with systemic lupus erythematosus: treatment and outcome; 164 Bassam Alchi and David Jayne: The patient with antiphospholipid syndrome with or without lupus; 165 Aine Burns and Bernadette Lynch: The patient with scleroderma-systemic sclerosis; 166 Lesley-Anne Bissell, Dwomoa Adu, and Paul Emery: The patient with rheumatoid arthritis, mixed connective tissue disease, polymyositis, Sjogren syndrome, or overlap syndrome; 167 Jean-Philippe Haymann and Francois Lionnet: The patient with sickle cell anemia; 168 Maarit Korkeila, Bengt Lindholm, and Peter Stenvinkel: The obese patient (metabolic syndrome); 169 Andres Cardenas and Pere Gines: The patient with hepatorenal syndrome; 170 Paul Goodyer: Kidney/ear syndromes; 171 Friederike Mackensen, Vedat Schwenger, and Heiko Billing: Kidney/eye syndromes; 172 Tim Eisen: The patient with renal cell cancer; 173 Christopher D. Mitchell: The patient with Wilms’ tumour; 174 Marina Noris and Tim Goodship: The patient with haemolytic uraemic syndrome/thrombotic thrombocytopenic purpura; Part 7: The patient with urinary tract infection; 175 Neil Sheerin: Urinary tract infection in the adult: overview; 176 Ased Ali and Rob Pickard: Infection of the lower urinary tract; 177 Mark Harber: Upper urinary tract infection; 178 Ased Ali and Rob Pickard: Complicated urinary tract infection; 179 Mark Harber: Urinary tract infection in a patient with a kidney transplant; 180 Heather Lambert: Urinary tract infection in infancy and childhood; 181 Rashad Barsoum: Schistosomiasis: the parasite and the host; 182 Rashad Barsoum: Schistosomiasis: clinical impact; Part 8: The patient with infections causing renal disease; 183 Vinay Sakhuja and Harbir Singh Kohli: Malaria; 184 Vinay Sakhuja and Harbir Singh Kohli: Leishmaniasis and trypanosomiasis; 185 Marion Muche and Seema Baid-Agrawal: Hepatitis B; 186 Fabrizio Fabrizi: Hepatitis C; 187 Saraladevi Naicker and Graham Paget: HIV and renal disease; 188 Hung-Chun Chen and Jan Clement: Hantaviral infections; 189 Jung-San Chang and Hung-Chun Chen: Dengue and other viral haemorrhagic fevers; 190 Norbert Lameire: Yellow fever, severe acute respiratory syndrome virus, and H1N1 influenza infections; 191 Emmanuel A. Burdmann: Leptospirosis; 192 Emmanuel A. Burdmann: Syphilis; 193 Emmanuel A. Burdmann and Vivekanand Jha: Rickettsiosis; 194 Rashad S. Barsoum: Schistosomiasis; 195 Raja Ramachandran and Vivekanand Jha: Nematode infections; 196 John Eastwood, Catherine M. Corbishley, and John M. Grange: Mycobacterial infections: tuberculosis; 197 John Eastwood, Catherine M. Corbishley, and John M. Grange: Mycobacterial infections: leprosy and environmental mycobacteria; 198 Raja Ramachandran and Vivekanand Jha: Renal involvement in other infections; Part 9: The patient with urinary stone disease; 199 Eric Taylor and Gary Curhan: Epidemiology of nephrolithiasis; 200 Bhavna Chopra and Stanley Goldfarb: Approach to the patient with kidney stones; 201 David A. Bushinsky and Orson Moe: Calcium stones; 202 Michel Daudon and Paul Jungers: Uric acid stones; 203 Michel Daudon and Paul Jungers: Cystine stones; 204 Benjamin A. Vervaet and Marc E. De Broe: Cell biology of nephrocalcinosis/nephrolithiasis; 205 Bridget Sinnott, Naim Maalouf, Khashayar Sakhaee, and Orson W. Moe: Medical management of nephrocalcinosis and nephrolithiasis; 206 Gauthier Raynal and Olivier Traxer: Imaging and interventional treatment: urolithiasis from the surgeon’s point of view; Part 10: The patient with hypertension; 207 Karlhans Endlich and Rodger Loutzenhiser: The structure and function of renal blood vessels; 208 Karlhans Endlich and Rodger Loutzenhiser: Regulation of vasomotor tone in the afferent and efferent arterioles; 209 Karlhans Endlich and Rodger Loutzenhiser: Tubuloglomerular feedback and autoregulation of renal blood flow and glomerular filtration rate; 210 O. Gonzalez-Albarrana and Luis M. Ruilopeb: The kidney and control of blood pressure; 211 Ulrich Wenzel, Thorsten Wiech, and Udo Helmchen: The effect of hypertension on renal vasculature and structure; 212 Helen Alderson, Constantina Chrysochou, James Ritchie, and Philip Kalra: Ischaemic nephropathy; 213 James Ritchie, Darren Green, Constantina Chrysochou, and Philip Kalra: Renal artery stenosis: clinical features and diagnosis; 214 James Ritchie, Darren Green, Constantina Chrysochou, and Philip Kalra: Renal artery stenosis: diagnosis; 215 James Ritchie, Darren Green, Constantina Chrysochou, and Philip Kalra: Renal artery stenosis: management and outcome; 216 Caroline Whitworth and Stewart Fleming: Malignant hypertension; 217 David Webb and Ian MacIntyre: Resistant hypertension; 218 Wolfgang Rascher: The hypertensive child; 219 Wolfgang Rascher: Treatment of hypertension in children; Part 11: The patient with acute kidney injury (and critical care nephrology); 220 Eric AJ Hoste and John A. Kellum: Definitions, classification, epidemiology, and risk factors of acute kidney injury; 221 Michael S. Goligorsky and Julien Maizel (with contributions by R Vasko, M Rabadi, and B Ratliff): Pathophysiology of acute kidney injury; 222 Norbert Lameire, Raymond Vanholder and Wim Van Biesen: Clinical approach to the patient with acute kidney injury: diagnosis and differential diagnosis; 223 Norbert Lameire: The role of novel biomarkers in acute kidney injury; 224 Norbert Lameire: Prevention of acute kidney injury: overview; 225 Norbert Lameire: Prevention

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