Truthfully, the new edition differs little from the previous one. Some important additions have been made, but even the preface basically is a repeat of the earlier edition. Going through the two editions page by page doesn’t show significant differences other than a change in the use of color in illustrations, section headings, and boxed highlights. I was disappointed that the new edition did not reflect the illustrations in the paperback edition Principles of Physiology, 3rd edition, by the same authors (Mosby, 2000). In comparison with the first edition book by Boron and Boulpaep, Medical Physiology (Elsevier Science, 2003), the Berne book does not flow as nicely, lacks the quality of organization, and certainly comes nowhere near the quality of illustrations.