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What is heart failure?; 1: Andrew L. Clark: What is heart failure?; 2: Andrew L. Clark: Heart failure syndromes; Epidemiology; 3: Theresa A. McDonagh and Kaushik Guha: The epidemiology of heart failure; The aetiology of heart failure; 4: Colette E. Jackson and Roy S. Gardner: The classical causes of heart failure; 5: Giuseppe Limongelli and Perry M. Elliott: The genetics of heart failure; 6: Stanley H. Korman and Andre Keren: Metabolic heart failure; 7: L. Swan: Aetiology of congenital heart disease; 8: Roy S. Gardner and Andrew L. Clark: Infective and infiltrative causes of heart failure; 9: Martin Denvir: Iatrogenic heart failure; Pathophysiology of heart failure: cellular and molecular changes; 10: Godfrey Smith and Rachel Myles: Intracellular calcium handling in heart failure; 11: Peter H. Sugden and Stephen J. Fuller: Myocardial energetics; 12: Alex Lyon: The failing cardiomyocyte; Pathophysiology of heart failure: systolic dysfunction; 13: Theresa A. McDonagh and Henry J. Dargie: The pathophysiology of heart failure; Neurohormonal adaptations; 14: Theresa A. McDonagh: Cardiac natriuretic peptides and heart failure; 15: Ben Szwejkowski, Sushma Rekhraj, and Allan Struthers: Vasopressin; 16: Stamatis Adamopoulos, Panagiota Georgiadou, and Vassilios Voudris: Cytokines and infl ammatory markers; The diagnosis of heart failure; 17: Diagnosing heart failure; Noninvasive investigation; 18: Roy S. Gardner: Basic investigation of heart failure; 19: Alison Duncan: Echocardiography; 20: Pushan Bharadwaj and S. Richard Underwood: Nuclear medicine in heart failure; 21: C. Parsai and S.K. Prasad: Heart failure imaged by cardiac magnetic resonance imaging; 22: Joanne D. Schuijf, Laurens F. Tops, and Jeroen J. Bax: CT imaging techniques; 23: Klaus K. Witte: Metabolic exercise testing in chronic heart failure; Invasive investigation; 24: Roy S. Gardner: Invasive investigation; Prognostication; 25: Roy S. Gardner: Prognostication; Comorbidities; 26: Andrew L. Clark: Diastolic heart failure; 27: Andrew L. Clark: Right heart failure; 28: Peter van der Meer and Dirk J. van Veldhuisen: The patient with heart failure and anaemia; 29: Darren Green and Philip A. Kalra: The patient with heart failure and renal dysfunction; 30: Mike Greenstone: The patient with heart failure and chronic lung disease; 31: T.J. Corte and S.J. Wort: Pulmonary hypertension in left heart disease; 32: Andrew Jamieson: Heart failure and diabetes mellitus; 33: Gregory Ducroq, Bernard Iung, and Alec Vahanian: The patient with valvular heart disease and heart failure; 34: Anita K. Simonds: The patient with heart failure and sleep-disordered breathing; 35: Nicola L. Walker and Anne McEntegart: Heart failure and arthritis; 36: Ashley Nisbet and Derek Connelly: The patient with heart failure and arrhythmias; Medical therapy for chronic heart failure; 37: Iain Squire and Andrew L. Clark: Angiotensin converting enzyme inhibitors and vasodilators; 38: Henry J. Dargie and Desmond Fitzgerald: ? -Adrenoreceptor antagonists and heart failure; 39: Sushma Rekhraj, Ben Szwejkowski, and Allan Struthers: Aldosterone antagonists; 40: John McMurray: Angiotensin receptor blockers; 41: Andrew L. Clark, Alison P. Coletta, and John G.F. Cleland: Therapeutic control of fl uid balance in chronic heart failure; 42: Andrew J.S. Coats: Digoxin; 43: John G.F. Cleland, Azam Torabi, Jufen Zhang, and Raj K. Chelliah: Antithrombotic agents; Medical therapy for acute heart failure; 44: Susanna Price: Inotropes, pressors, and vasodilators; Nonpharmacological management; 45: Massimo F. Piepoli and Andrew L. Clark: Cardiac rehabilitation and chronic heart failure; 46: Lynda Blue and Yvonne Millerick: Nonpharmacological management; Device therapy for heart failure; 47: Rachel Myles and Derek Connelly: Implantable cardioverter-defi brillators in heart failure; 48: Badrinathan Chandrasekaran and Peter J. Cowburn: Cardiac resynchronization therapy; Surgical therapy for heart failure; 49: Nicholas R. Banner, Andre R. Simon, and Margaret M. Burke: Heart transplantation; 50: John R. Pepper: Revascularization and remodelling surgery; 51: Emma J. Birks and Mark Slaughter: Ventricular assist devices, including intra-aortic balloon pumps; 52: Andrew Murday: Mitral valve surgery in heart failure; Ventilatory strategies in heart failure; 53: Mhamed Mebazaa and Alexandre Mebazaa: Ventilatory strategies in acute heart failure; Disease management; 54: Suzanna Hardman: Multidisciplinary heart failure management programmes; 55: Miriam Johnson: End of life; 56: Jillian P. Riley and Martin R. Cowie: Monitoring; Future therapies; 57: Andrew L. Clark, Henry J. Dargie, Roy S. Gardner, and Theresa A. McDonagh: The future

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