Coarse-Grained Modelling of DNA and DNA Self-Assembly

生物物理学

售   价:
884.00
作      者
出  版 社
出版时间
2014年08月15日
装      帧
平装
ISBN
9783642436529
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页      码
176
语      种
英语
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图书简介
This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker — the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.
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